In addition to the modern day fuel composition and why our older R4's can't cope with it.
Premium unleaded fuel was introduced since 1985 and was never a problem for our R4's in those days since I drove 90.000 km per year without any problem whatsoever
The "problem" started with the introduction of premium unleaded 95 (or E5) with an addition of 5% ethanol and lower amounts of benzene and octane.
Ethanol takes more time to start burning and that's why the ignition has to start earlier (advance) and as Robert (harbourseal) correctly explains, as fas as advance and beware of pinking.
The ethanol is causing the trouble and has to be replaced with octane, ethanol also increases fuel consumption and ethanol decreases power performance of our elderly engines.
Better is to fill your tank with Shell V-power (97), Total Exellium (98), Texaco Superplus (102?) en Aral V-power (98).
I live nearby the German border and luckily there's still the old super 97 and much cheaper than the greedy dutch fuel prices, sadly greed rules the world...
In the near future things will be more problematic with more ethanol coming up.
The only technical solution for our R4's in the future is to switch to a full electronic ignition AND a new camshaft. We can advance the ignition but the camshaft timing e.g. valve opening and closing has to be adjusted accordingly.
Or as an alternative one could experiment with changing the punch rod length and rocker gaps
